The contribution is aimed at an evaluation of the structure and spatial differentiation of inhabitants of Slovakia on the basis of their denomination. The evaluation of the structure of religion was made in two hierarchic levels: - regional – allegiance of population to the given type of religion according to districts was evaluated (data processing and evaluation was carried out on the basis of old administrative units, i.e. 38 districts), - local – allegiance of population to the certain type of religion according to settlements was evaluated. The evaluation on local level revealed more detailed characteristics of the religious structure of population; on regional level we can separate more coherent zones of religious structure. As to the amount of the denomination types, the religious structure of Slovakia is heterogenic. There are 4 basic types appearing more significantly and forming spatial coherent zones in the direction west-east.